Classifications: central nervous system agent; narcotic (opiate) antagonist
Pregnancy Category: B
0.02 mg/mL, 0.4 mg/mL injection
Analog of oxymorphone. A "pure" narcotic antagonist, essentially free of agonistic (morphine-like) properties. Thus, it produces no significant analgesia, respiratory depression, psychotomimetic effects, or miosis when administered in the absence of narcotics and possesses more potent narcotic antagonist action.
Reverses the effects of opiates, including respiratory depression, sedation, and hypotension.
Narcotic overdosage; complete or partial reversal of narcotic depression including respiratory depression induced by natural and synthetic narcotics and by pentazocine and propoxyphene. Drug of choice when nature of depressant drug is not known and for diagnosis of suspected acute opioid overdosage.
Shock and to reverse alcohol-induced or clonidine-induced coma or respiratory depression.
Respiratory depression due to nonopioid drugs. Safety during pregnancy (other than labor) (category B) or lactation is not established.
Neonates and children; known or suspected narcotic dependence; cardiac irritability.
Adult: IV 0.42 mg, may be repeated q23min up to 10 mg if necessary
Child: IV 0.01 mg/kg, may be repeated q23min up to 10 mg if necessary
Postoperative Opiate Depression
Adult: IV 0.10.2 mg, may be repeated q23min for up to 3 doses if necessary
Child: IV 0.0050.01 mg/kg, may be repeated q23min up to 3 doses if necessary
Child: IV 0.01 mg/kg into umbilical vein, may be repeated q23min up to 3 doses if necessary
PREPARE: Direct: May be given undiluted. IV Infusion: Dilute 2 mg in 500 mL of D5W or NS to yield 4 mcg/mL (0.004 mg/mL).
ADMINISTER: Direct: Give 0.4 mg or fraction thereof over 1015 sec. IV Infusion: Adjust rate according to patient response.
INCOMPATIBILITIES Y-site: Amphotericin B cholesteryl complex.
Assessment & Drug Effects
Patient & Family Education